In my experience, which is primarily related to using Roon, the answer to your question requires separating the server from the streamer since they perform two separate functions. In the case of using Roon, the server runs Roon server, or Roon Core, which manages music files, streaming services, and the audio devices on your network. The streamer operates as a Roon endpoint, which clocks, processes, and transports the digital signal to a DAC where it is converted into an analog signal. In some cases, the server and streamer exist in a single chassis, like with the Antipodes K50, the Grimm MU1, and others.
I have not heard noticeable sonic differences in the servers that I have owned. However, I have heard meaningful sonic differences in streamers, with the best sounding streamer I have owned being the Sonore Signature Rendu SE Deluxe, which is currently in my main system. If I didn't already have the Sonore streamer, the other one I would try is the Innuos Pulsar.