I think the answer to the question starts with how your power is, without conditioning. (Surge protection is a different question). I’m sure that some find power conditioners to improve the overall sound of the system, but wonder how many of those folks are living in apartments or are on grids that are nasty/out of date?
I’ve tried various power conditioners over the years, and my system always sounded better without them.
Insofar as "surge protection" is concerned, I do use a whole house plus a surge board on my big isolation transformer (10 kVa in a 400 lb case outside). I don’t use point of use on that system, but go straight into the receptacles (Porter Ports, no longer available).If a close lightening strike all bets are off. We do get the fringes of some seriously crazy storms in Austin, but not like Oklahoma or some other parts of Texas. (hee-ha). :)
I have a whole bunch of things here. A ZeroSurge supplies power to my vintage Quad 57s in the second system, and there, it does not necessarily interfere with sonics. (I’m simply keeping the panels charged).
But on the main system, I went to some lengths to sort fo the power from the service entrance, using commercial electricians for a more than standard residential system.
Truth be told, the power where I am in Austin is better, overall, than what I had in the lower Hudson Valley of NY. (Old infrastructure).