I can connect left channel output of the preamp to a 100 watts power amp and the right channel to 250 watts one, and expect both the left and right speakers sound with the same volume just delivering a different headroom quality?Yes, if the gain of both amplifier are identical and the required output power of both amplifier is less than 100 watts to provide that degree of loudness (volume).
Let’s put it this way, the max. output power of an amplifier is the top speed of a car, the volume control is the cruise control of a car.
If you set the cruise control at 50mph on two cars, one car with top speed of 100mph and the other car with top speed of 200mph, both car will run at 50mph as the cruise control setting.
Now, if you set the cruise control at 130mph on both cars, the one with top speed of 100mph will run at 100mph and can’t go any faster, the one with top speed of 200mph will run at 130mph as the cruise control setting without problem.