Harbeth speakers will work well with lower-powered amps, but they ain't gonna play loud. That may or may not be important to you. From my experience with audiophiles, most like to listen at fairly high levels, although, like most things in this hobby, it's something that's often denied. As to Mastersound, I haven't heard the 300b amps, but I did have a Duo Trente. Excellent build quality, but it was, to my ears, very neutral sounding. Again, most audiophiles will claim to like neutral-sounding stuff (more of the great lie) so if you're among them, the Mastersound will be great. Also very quiet. Myself, I prefer something with a bit more of what people seem to want out of a tube amp, whether they admit it or not. Anyway, the Harbeths are excellent and my experience with Mastersound has been very positive, so I guess you'll be fine. Good luck