Try it. I've run two sets of speakers out of my pre-processor. One balanced to one amp and the other single ended to another amp. This is so I can use one pair of speakers for two channel and the other for surround. I turn off the amp for the speakers I'm not using. Haven't had any problems, though I just started using a second pre-amp for the two channel because I wanted to see what tubes would do.
--Neil
--Neil