room placement question

I'm looking into buying a new house and I'd like to make sure that the room I choose to place the speakers will work well (unlike my current place where I didn't think about this at all).

I have seen a lot of floor plans that look similar to the one in the link below, and I just wanted to see what are people opinion on how well the speaker could be placed in the "great room".

http://www.stonecrofthomes.com/floorplans/stonecroft-charleston.pdf

I was thinking of placing the speakers on the window wall, but my concern is that there's a solid wall on the left side of the room, but on the right side of the room there is no wall since it opens to other parts of the house. Is this lack of symmetry something to be concerned about?

Thanks.