Rhythmic F12SE setup using line in

I have two Rythmiks of this make. I have done a lot of work to dial in my subs (I have a third REL). Ultimately, the best thing to do was buy a mini DSP and integrate subs that way. Highly recommended.

https://www.minidsp.com/applications/digital-crossovers/194-subwoofer-integration-with-minidsp

I would prefer to dial in my sub without the use of the minidsp. 

I totally sympathize and tried for a very long time -- arduous, even onerous work -- to measure, move, listen, dial in and out, etc. to get the bass right. A good friend of mine who's been an audiophile for 30 years with an incredible and well-designed system (he also builds audio) has DSP for bass. It really does not "pollute" the sound in the way that many worry about for the higher registers. Keep in mind, this is limited to the subs only.

In other words, the benefit gained by dialing in subs (and room) far outweighs the (actually small) detriments of adding dsp to the system. For me, this was evident enough to help me reconsider and reject my bias against dsp.

Ok, so I better understand, I would run my sub line out from my preamp to the miniDSP, let it do its thing, and run that to the sub. My R11’s would still run full range analog directly from the preamp. The sound processing for the sub only would be based upon room characteristics & R11 output. Is that correct?

You’ve got it exactly. The diagram below could have an additional sub added and with the other miniDSP model you were indicating, perhaps more. But you have the general principle exactly right.