I have developed over years a severe aversion/sensibility for all exacerbating high frequencies artefact. I had to change my integrated amplifier 3 times, my DAC 3 times, my speakers 3 times, my music server 2 times along with various cable changes. The worse error I made was to hang-on to my Spendor D7 not realizing they were the biggest source of high frequencies listening fatigue.
In the end, after all these changes (integrated amp Accuphase E-370, music server Innuos Zenith MK3, speakers Pierre-Etienne Léon Kantor S3.2), I noticed that my PS Audio Directstream DAC MK1 (even after the output transformer upgrade) was giving me some listening fatigue, but I could have stopped there. But then, my old Micromega CDF1 CD player gave out - I was only using it very sparingly with most of my listening being done through the DSD MK1 DAC. After some shopping around for a new CD player, I was intrigue by the Marantz SACD 30n: it was both a CD player and a DAC accepting USB input, and was doing a DSD conversion (which I found much smoother than PCM when properly implemented) using the Marantz Musical Mastering (MMM) digital-to-analog converter as a lesser version than the one available on their Reference SACD and CD Player SA-10. To this day, I have not found one single PCM implementation that did not cause me listening fatigue (be it DAC chips, R2R, Chord pulse-array). To my surprise, after some serious listening, I found that the Marantz SACD 30n provided me with more details, more natural tones, and warmer/richer medium frequencies than the DSD MK1 DAC, so much so that I sold the DSD MK1 DAC and replaced it permanently with the Marantz 30n.
It should be mentioned that I listen almost exclusively to Sacred Choral chants and listening fatigue can come very very quickly if the high frequencies (sibilance) are too present. I am now retired, bought my Marantz 30n back in March 2022 (Capitalsound.ca for CAD$3,800) and do not plan to upgrade my sound system any time soon.