I have a friend with a similarly sized room using Ls3/5s to good effect. He has a Quad pre/power rated at 100W, but it's rarely turned up very far. He has no sub !
I think overall the S3/5 probably would work for you, but I don't think you'll have much margin, so my answer would be a cautious yes. If you had listed rock music, I think I'd say no.
The sub will help a lot, particularly with respect to preventing the underpowered sound, since much of the power of an amp is required for the lowest frequencies, which are not reproduced by the S3/5.
I think overall the S3/5 probably would work for you, but I don't think you'll have much margin, so my answer would be a cautious yes. If you had listed rock music, I think I'd say no.
The sub will help a lot, particularly with respect to preventing the underpowered sound, since much of the power of an amp is required for the lowest frequencies, which are not reproduced by the S3/5.