Listening to these amazing speakers as I type. I've got about 500 hours on them and they are a spectacularly precise, transparent and wholly satisfying speakers.
I tried both biwire mogami 3104 and synergistic research atmosphere level 1 single run. Honestly, once broken in, I prefer the synergistic to the biwire mogami. The mogami sounds slightly richer, but I lose transparency, speed and focus when compared to the synergistic. The synergistic are a whole different ball game. The synergistic cables create ghosts in the room. The Maggie's hinted at this. The proacs are supernatural in their presentation. They are so transparent, that the mandatory warmup on my preamp is so much more noticeable. It doesn't get truly "hallucinogenic" sounding until about 30-45 minutes, but it when you reach that time, it's like an aural thrill.
Now honestly, I don't know if it's that the speakers don't respond well to biwire with my equipment, which would go against conventional wisdom around here with proac, or that the mogami is just that much worse of a cable than the Synergistic. But I cannot get the magic focus and coherency with the mogami biwired as I do with the synergistic single run. But at the end of the day, we all must trust our ears, and do what we feel sounds better to US. If it sounds good to YOU, then it sounds good. Many people swear by biwiring the proacs. Didn't work out for me, with my given cables. Many people will also say that higher end single in will out do a mediocre biwire.
Its amazing that an entry level high end pre like the LS -17 can sound so amazing, but with the dac 8, ds450, and the D48r, it's actually quite stunning. I can't imagine how bonkers a ref 5se would sound like to replace it. Best part? The sound at low volumes, completely satisfying with full projected images at proper size. 👏