#1stworldproblems :) But seriously it does depend on the design as stated above. I like the layout of my tube amp inputs front left corner, captive AC cable back left corner, binding posts center. I don't move or change things much so not as much a bother to me.
Power Cord Placement
Imagine the back panel of a high quality power amplifier or preamp. Where's the inlet socket for the power cord? Sometimes it's to the far left, sometimes to the far right, but what really annoys me is when the inlet is right in the middle. I cannot think of a more difficult location when it comes to distancing power cables from audio cables. It makes want to consider battery powered equipment!