Here is my conclusion with the Schiit Wyrd, Regen, and the Jitterbugs in my system.
First off, I tried every single configurations with these units.
The 2 Regens plugged together using the hard USB connection and the 2 Jitterbugs plugged into my Bryston BDP-2 provided the best overall sound quality. And boy does it sound great! Very deep soundstage, but also very natural sounding throughout.
Funny, I found out with all the gyrations that I made, was that my linear power that I use to power the Regens is sensitive to power cords. I ended up using a Mad Scientist power cord that was plugged into a Bybee power purifier.
The Schiit Wyrd just wasn't as good as the Regens or perhaps it just wasn't synergistic with the Regens. Every time the Wyrd was in the chain the soundstage became out of focus. Vocals that were centered became all over the left, center, and right.
I even tried the Wyrd in front of my external hard drive and I still didn't like the result.
So, the Wyrd goes back for a refund. I would have kept it if it showed it's worth somewhere in my system.