I would steer clear of 2-wire Romex. The hot and neutral run parallel along the flat length and this creates an RFI antenna. I use 10/3 Romex (orange sheathing) because the three wires are twisted, which helps attenuate common mode noise. I use the third conductor as a ground (make sure to tape the visible ends green) and clip the bare copper grounding conductor. This also has the added advantage that it can be converted to a 240V branch circuit in the future.
Isolated ground in dedicated room/new construction?
Am building a custom house from the ground up with a dedicated listening room. Room will have have 3 dedicated 20 amp home runs for the system using 10 gauge 10/2 romex with ground, terminating with PS audio IG 120v outlets. Romex NM wire with plastic boxes, no metal boxes or conduit. House will have 400 amp service utilizing two 200 amp panels. With this set up is there any point in setting up an isolated ground and how do I go about it? Is it even feasible?