Is there any wall on the side that opens up? I think you have two considerations. One is the volume of the room and the other is the sidewall reflections for speaker placement. If there is a stub wall or other projection, then I would position the speakers using that as my guide and forget the added area for positioning purposes.
Now, for loudness considerations and amp size, the recommendations above are good.
Now, for loudness considerations and amp size, the recommendations above are good.