At the beginning of the pandemic I tried out a Cambridge CXA80 and had some fatigue and than sort of went away after getting use to it, but occasionally would get fatigue. Sold it and tried a vintage Marantz 2270 and also had slight fatigue but not as bad as the Cambridge. Sold that off and picked up a McIntosh MA252 hybrid and in the beginning had some fatigue but got use to it and sounded great with Tidal MQA and vinyl. Sold that off and picked up a Primaluna Dialogue Premium tube amp no fatigue but than switch the two front 12AU7 tubes and got initial fatigue but went away after I got use to it. I hung on to that tube amp until recently and never had fatigue after the initial swap of tubes. Now picking up a Technics su-g700 and will see how that turns out. I may end up back with a Primaluna if things don’t work out with the Technics.
P.S. my speakers of choice and they never changed since the beginning of the pandemic were my trusted JBL 4312SE 70TH Anniversary edition.