I found cabling to make a significant difference with my Gallo 3.1 speakers. I used the following amps with mine. Response Audio modified Jolida 502b, Mac 6900, Wyred 4 sound ST1000, Clayton S40, Unison Research Unico SE,and Ayon Spirit II.
Of the integrateds the Ayon was the best overall with sparkling highs, liquid midrange and decent but slightly soft bass. The Unico SE hybrid was very, very good. It was fast with tremedous grip on the bass, better than all others I tried.
When I had the Mac I was using all Acoustic Zen wire and I was dissapointed in the sound, it was flat, closed in, and muffled. It is the only MAC I have had or heard and given it's reputation I don't think it was the amp as much as the synergy with the wire and the speakers.
After I switched to all Morrow wire I felt I could hear the character of the different amps much better.
The Clayton is only 50 watts a channel Class A all the way and it was plenty of power and souded very good with a tube preamp.
What kind of music do you listen to?