I have a record which has been played extensively - hundreds of times on a low fi system, and many hundreds on a high end setup. It has been ultrasonically cleaned.
I also have a sealed copy of the same record, played only a few times. There is little difference - similar enough that you cannot differentiate them unless cuts are played alternately.
I also have an audiophile record which has lost its lustre over some hundreds of playings on a high end system. So I guess the answer is, "depends".