my experience was just the opposite of Bufus - new out of the crate my speakers (not quads)were very rolled off - muffled in fact. i didn't count the hours but i let them run for 3 to 4 days and the opened up just fine. be patient.
botrytis, i think the only way you will know for sure is to buy a lot of speakers and break them in to see for yourself if there is a difference. Please do not trust the experiences of others - we lie as lot just to get in print.
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