MSB Customer Support suggested the following settings for my MSB Premier DAC:
1) DAC to Integrated Amp (using a pre-amp)
DAC Output level = high
DAC volume = 96-98
COMMENTS: I switched the DAC Volume back and forth between 96 and 98. I do not notice a sound difference but decided to keep the DAC volume control at 98.
2) DAC to power amplifier (Direct to power amplifier):
DAC Output level = low
DAC volume = Start at 0, increase as needed.
I hope this helps. If you have more questions, please contact MSB Customer Support.