This really depends on the equipment you are using. Since the node currently doesn't have a USB output, you are likely goin to have to settle on digital coax which will likely be your best performer.
That being said, it really depends on the gear. If I was using Chord gear, BNC will outperform any other input. If you are running Rockna, I2S is the best input but if not available, next best is AES and I have customers whoe report "glorious" performance between say the Bricasti M5 and the Rockna Wavelight via AES.
There is no universal truth on this one. The gear matters.