I have also found that the sound changes with the direction of the fuse. In one way it is relaxed with a very clear mid-range specially the voice with a little loose bass. The reverse direction produces a very fast, punchy sound with a controlled bass but it had a tad hazy mid-range specially the voice.. I wanted to get both but it is not possible at least with the current stock fuse.This is not caused by reversal of the fuse but how it makes a connection. Quite often by reversing the fuse you get a better connection because the fuse sits better in its holder and thus there is a lower voltage drop across it.
IOW its the connection, not that its reversed. If the only way to get the fuse in the holder is by removing the fuse cap, you might not have much option but to reverse the fuse to see if the contact is better.