Tubes are definitely the way to go. Consider avoiding entry level tube amplifiers because as soon as you get it you’ll have an urge to upgrade. Some people are perfectly happy, but I sense you probably want more.
If possible make an aggressive purchase in the mid range of the product lines you wil pursue.
Room size is a good size.
If I had to do it again I would pursue speakers that don’t require a lot of power so you can take advantage of lower wattage tube amplifiers, and there are many gems out there.
I’m currently using 300 w mono amplifiers.