There's all kinds of possibilities based on your opening comments and there's lots of good suggestions here. Playing with placements and room treatments may do the trick. If you want to try different cables, don't want to pay a king's ransom and get the best performance you're likely to find for the dollar spent, try PNF Audio.
Fatigue reducing interconnect?
I am relatively new to this hobby and have assembled a system consisting of Musical Fidelity A5 Integrated, A5 CD Player, and Energy Veritas 2.3i speakers. Kimber Hero interconnects and Kimber 8tc cables complete the setup. While I notice much improved vocals, detail, bass, imaging, and transparency over my previous Adcom/Paradigm setup, at moderate to higher sound levels I am experiencing a brightness in the treble (and upper mid?) region that reduces listening enjoyment over longer periods. As a change of cd/amp/speakers/speaker cable (requires carpet work) is not economically feasible, I am wondering if you have a suggestion for another, similarly priced interconnect that may retain the above mentioned positive qualities while reducing a degree of harshness/fatigue. Thanks.