The main things that matter in digital are the source files the ADC that converts and the DAC that converts. If your DAC isn't up to modern specs in regard to isolation, filtering and reconstruction then these other superfluous items can make a difference but if everything between works to spec it's not that important. Consider how much time and money you have invested in your internet modem the device that reconstructs the analog to digital signal. So yes everything matters some more so than others.