Several good experiential opinions are offered above, none exactly alike. KT what that tells you is, like everything else, you'll need to experiment in order to determine what works best for you with your own equipment in your own room. I also realized significant benefits by not having anything placed between the speakers so my rack is along a sidewall. However regarding my particular component synergy, I also found that longer interconnects were detrimental compared to shorter ones, while longer speaker cables resulted in less degradation than with longer interconnects & shorter speaker cables. Note that I prefer networked speaker cables, so those longer lengths are accordingly inherently compensated. The equipment rack, also containing a single stereo amp, is now all on a sidewall. In this way I was able to use shorter AC cords as I wired a dedicated AC line directly to the rack location, & my AC conditioners are also located there locally.
Again, all of these advices tell you not a whole lot about what will work best for your setup, but do offer many good suggestions about what might be most advisable for you to try out.
Again, all of these advices tell you not a whole lot about what will work best for your setup, but do offer many good suggestions about what might be most advisable for you to try out.