ProAc Response D Two is worth considering, if you’re able to audition.
Natural sound, excellent imaging and soundstaging (somewhat holographic), and convincingly resolving. Can sound somewhat forward, perhaps dynamic, but in a way that the music comes towards you; you don’t have to "hear into" their soundstage. They play well at moderate volumes. They are resolving enough to show differences in amplification, cables, and everything else upstream; yet are not difficult to place for excellent imaging. Your Ayre integrated amp and CD player may be a good match for them, and the D2 has bi-wire speaker cable terminals.
I haven’t had the chance to hear Harbeth, or the SF Liuto monitors, but they sound like very good options as well.
The ProAc D38 would be a good floorstander for your room size, speaker placement width, and distance to seating position. I have them in a 13x17 room, 9-10 feet apart, and about 9-10 feet from seating position. I usually listen at moderate volume, but they play well at low and somewhat high volumes with my Simaudio 600i integrated amp and Simaudio Supernova CD player.
Good luck with your search. A lot of good input from everyone.