My server is an Aurender N100 and has only USB output. I’ve tried two different DDC’s in order to convert to I2S or SPDIF for my Gustard R26 DAC and the better one is the Gustard U18. (I haven't tried the Iris 12th or other DDCs so I'm not sure how the U18 compares.) I’ve tried the coaxial connection and the HDMI connection. Coaxial sounds best. The I2S through HDMI sounds a bit bright and more sterile.
My HDMI cable is a 0.75 M Audioquest Firebird, a $1600 new cable although it comes up frequently on US Audio Mart for much less than that. My coaxial cable is a custom silver, highly shielded cable made by Igor Kuznetsoff, which is likely better quality that my Firebird.