Does creating a loom in cables in a system make a significant difference?

Maybe the loom theory (next to sales) is to have cables with the same design principles and therefore the same kind of enhancements/or lack of distortions. Mixing cables can introduce distortions with different kind of parameters that can bring down the whole experience. One cable sound airy, but is bass shy, the other one scoops the sound, the other one chokes the high end detail, the other one is more susceptible of noise (witch can be a problem when it is used on the wrong spot/or is a heavy noise transmitter itself. Sometimes changing one cable can have effect on the other cables.I like to experiment and mix cables, connectors and equipment. Always start with the best cables at the source (distributor, power cables, interconnects/digital and at last speaker cables and keep them separated as much as possible (or cross at 90 degrees)

Maybe you are correct. Distortions is not the right word. Every cable is losing some musical information. But if the loom is losing information at only one point (for example detail) it maybe will sound better at the end instead of losing information on multiple points because of other sound signatures due to masking. This is not my personal view, but I am thinking out loud why a loom could sound better.

I guess my point is, just keep adding better cables for your tastes/system as you see fit, and I don’t think that in any way necessitates sticking to one brand. Just my take and experience.

+1. I will always add better cables when I have the budget .At the moment my cables are fine. I am now saving my money for a better DAC. It is all about balance in this hobby of ours.

And to answer the OP's question. I think there is no extra synergy in a full loom of one vendor. It don't have to cost a lot of money but your cables should be in line with your equipments potential and grow when your system gets better.