Tubes have a huge effect on SQ, in every level of the circuit.
Tube production is going away.
Tube production has very low quality control.
Tubes degrade as soon as you plug them in.
Tubes have poor industry standards such as AES/EBU.
Tubes are hot and heat up your room.
Tubes take time to warm up.
Tube equipment will shock you.
Tube amps are generally low power.
Tubes degrade slowly and you don't realize it.
Tubes sound wonderful and buttery.
Tubes are so frustrating because they sound better than SS.
Tubes are expensive, because you are always searching for better tubes.
Tubes are expensive because you have 30 extras in another drawer you couldn't throw away.