Do speaker cables really make a difference ?

Everything in the signal path impacts the sound quality. How much of an impact depends on the synergy with the other components in the system, particularly in this conversation, as one would expect, the speakers. Many speakers are very forgiving, if you will, when it comes to speaker cables. My Apogee Acoustics Duetta II Signature full range ribbons speakers (recently completely updated and upgraded by Music Technology in VA) are on the other end of the spectrum and extremely speaker cable sensitive. So much so that the speakers would sound like crap in various ways depending on the myriad of unsuitable cables. I know there are other speakers cables that would sound good, but there are many at various price points that simply won’t work well. I’ll go with Jason Bloom’s advice from 30+ years ago and won’t even entertain at this point switching out my Symo cables I’ve had since soon after the Apogees were originally purchased by my dad in 1988.