do cartridge lead composition make a difference?

Dear Lleall: IMHO yes it makes a difference for the better or worse depends what the choice. IMHO does not depends on synergy not only with the cartridge but with any thing else.

I think you must choose the best alternative that can degrade the less the cartridge delicate signal.

A good silver wires are IMHO the way to go but not only looking for the silver wire it self but for the female wire connectors that always makes a difference too and as with the lead wires silver is the way to go.

Regrads and enjoy the music,
R.

Do they make a difference?

Yes

Does it depend on synergy with the cartridge?

No

Thanks, Raul, for taking the time to answer.
Much appreciated.
Sincerely,
Lea