Directional wires/cables

Is there any reason to support the idea that cables, interconnects or any other kind of wiring can be considered directional? It seems that the theory is that carrying current will alter the molecular structure of the wire. I can't find anything that supports this other than in the case of extreme temperature variation. Cryo seems to be a common treatment for wire nowadays. Extreme heat would do something as well, just nothing favorable. No idea if cryo treatment works but who knows. Back to the question, can using the wires in one direction or another actually affect it's performance? Thanks for any thoughts. I do abide by the arrows when I have them. I "mostly" follow directions but I have pondered over this one every time I hook up  a pair.