Certainly 2 MC275 are a good solution. However, think about the heat and the expense of buying/rolling/replacing that many tubes. Might not be an issue for you.
With 2 identical amps you could:
1. Operate each as monoblock and have them reproduce the full bandwidth to each speaker.
2. Have both amps operate as 2-channels, and have amp A feed mids/trebble from channel 1 and bass from channel 2. Same for other amp. Dividing the frequencies prior to the amps would still need to be dealt with.
3. Have both amps operate as 2-channel, but now have amp A drive hi/mids of left and right speakers and amp B drive bass on both speakers.
Keeep in mind the 501 are monoblocks, so they couldn't drive both speakers.
I'm personally inclined for tubes for hi/mids and SS for bass, provided a crosssover sits in front of them. Maybe a 501 is too much (power and expense). Maybe a 252 would do - depends on your speakers and budget, of course. This would be like my option 3, but with SS for bass. I don't know what advantage is there to have with ttubes for bass.
With 2 identical amps you could:
1. Operate each as monoblock and have them reproduce the full bandwidth to each speaker.
2. Have both amps operate as 2-channels, and have amp A feed mids/trebble from channel 1 and bass from channel 2. Same for other amp. Dividing the frequencies prior to the amps would still need to be dealt with.
3. Have both amps operate as 2-channel, but now have amp A drive hi/mids of left and right speakers and amp B drive bass on both speakers.
Keeep in mind the 501 are monoblocks, so they couldn't drive both speakers.
I'm personally inclined for tubes for hi/mids and SS for bass, provided a crosssover sits in front of them. Maybe a 501 is too much (power and expense). Maybe a 252 would do - depends on your speakers and budget, of course. This would be like my option 3, but with SS for bass. I don't know what advantage is there to have with ttubes for bass.