Placed two Mark Levinson No23's on a high shelf 25 years ago by myself...at 70 lbs each....and did not touch them until recently. My two sons-in-law got them down.
In another system I have a single Bryston 4B cubed coming in at 42 pounds.
At my current age, not sure I would hear meaningful difference but have never swapped them to compare.....but 42 lbs is certainly easier to handle than 70 lbs.....but I negated the advantage by using the Bryston with Egglestonworks Andra II's which come in at 215lbs each.
When I move to my retirement home, definitely going with quality headphones...only.
It is horrible getting old, but it beats the alternative.