My speakers are in front of a bare wall and my gear is off to the side. Speakers are bi-wired with long runs of Kimber (I think) 6TC and 8Tc (but that was a long time ago, so I am not positive) and interconnects are 1.5 m of balanced Kimber Silver Streak (I went with 1.5 m because once upon a time I needed more flexibility with gear position).
I personally think my system is sounding fantastic at the present, but this thread has got me rethinking what the sonic advantages might be if I put the amp (Cary V12) on the floor between speakers with short cables and hooked amp to pre with long balanced interconnects. I would need a much longer power cable to do that, however.