Short speaker cables and long interconnects. Over the last fifty years I have tried both. Depending on your equipment, generally the quality of the interconnects between preamp and amp are more important than whether or not they are single ended or balanced.
‘Also depending on the quality and specific components, typically the quality of the speaker cables will mater most, then the amp power cords, then the interconnects, then the rest of the power cords. Most importantly, each is additive, each improving the sound and in aggregate can make very substantial sound quality improvement.
It would be helpful to know more about your equipment and venue. There is a place under your user ID, under virtual systems. Then you can post only once.