Break-in procedure

Is there any downside in connecting one speaker out of phase with respect to the other during break-in (i.e., pointed at each other) or, by corollary, is there any directionality issue to consider if one speaker is out of phase with the other? I am also considering purchase of a Conrad-Johnson preamp that inverts phase- so I will need to make an appropriate adjustment in the cabling (my digital source does not have a phase invert feature). Is this an issue considering that the speakers have been running in an opposite (i.e. normal) configuration?