If the speakers are properly designed for bi-wiring then it will make a difference but a lot of speakers have four terminals and they're not internally set up on the crossover to be bi-wired properly but it does make a difference if the speakers are properly designed, I have the monitor audio platinum 200g2 and when I bi-wired them the sound stage opened up even more.
Biwiring make any sense?
I am on the verge of adding new floor standers to my setup as my room has enlarged. Options being considered are KEF R7 Metas and PSAudio Aspen FR10's. Both have biwireable terminals, the KEF has a jumper switch and the PS has jumper wires to bridge the terminals. The other option from dealing with the jumpers is to biwire the speakers. In this case I could run a banana and a spade off each output terminal. Is this even worth considering? Biamping is not something I'm interested in, as I already am running off an integrated amp. I had a pair of BassZillas before, each one of which had 3 sets of terminals, the top 2 being biwired, but that's a different deal (I don't have those cables anymore). Speaker comments would be welcome too. Amp is PSAudio Spectral Strata w/150 watts into 4 ohms.