Unless you have the amps already laying around, and just want to try it, go ahead. It can't hurt anything. If you are going to buy the amps; bad idea. The Quest are not that difficult to drive. I had the SL3 and the ReQuest and liked them both. To pick between a 402 and 275 would just be a matter of your taste, room size, listening volume, etc. I've never had a chance to listen to ML powered by Mac, but if I had to guess, I think it will sound very good. If you don't think the 275 is enough, you might want to consider a vertical biamp with 2 275's. You will get more power and not have to worry about the results you get from using 2 different amps.