I have the 21A also. The standby mode keeps the tubes' filaments heated, so that the warm up time of the tubes is less than 15 minuted vs. an hour or two from a cold start. However, the rest of the tube is not powered, thereby it's life should not be severly impacted. In fact, the opposite may be true; the tubes' life may be extended due to the tubes not facing the harsh turn-on currents every time you power up the preamp. This is also the same as my other preamp, the Audible Illusions L2 preamp.
If you're not going to listen for a while, like a few days or so, I would disconnect power to the pre.
If you're not going to listen for a while, like a few days or so, I would disconnect power to the pre.