If the manufacturer of both components has a balanced design then that is most likely whatever they used (single ended or balanced) will sound better. The manufacturer of my components (Audio Research) uses a fully balanced designs and recommends using balanced interconnects… I tried both, I couldn’t tell the difference. So, I went with balanced as it is the future of newer gear. I am sure Audio Research put a lot of effort into converting to single ended internally in case you used it… less expensive brands will probably not. So, using the native component mode might be most appropriate.