Depends very much on the room, but I found with my former Eidolons that a slight toe in provides a more ambient 3D sound field (preferred), than a toe in which faces the listener directly.
My set up suggestion is to do it first without the spikes. Have the speakers facing you directly. Then twist/slide them wider, 2 or 3 degrees at a time and see how they sound each time. Once they sound their best, you can install the spikes. Make sure you mark the final position on the floor before placing the spikes as the speakers will shift as you do so.