Attention Horn Owners

I don't know if you've seen measured specs and/or reviews from Stereophile, but here is one account, https://www.stereophile.com/content/audio-note-e-lexus-signature-loudspeaker-audio-note-espe-he-august-2008 May, 2006 issue has specs on Lexus version, Atkinson measured 92.5db sensitivity, also stated, "I don't think the speaker will make significant demands for current on the partnering amplifier, which, in combination with the high sensitivity, makes it very suitable for use with flea-based single-ended amplifiers". Based on those specs and Atkinson's conclusions the 300B should work with the AN-E. I'd  try out some subs before concluding your not a SET guy. I'd also suggest REL's, they are unique in their designed to connect to high level connections on amp binding posts. I use two with my modded Khorns and they made all the difference, not just lower fundamentals in bass, but sound stage, imaging, better tonal balance as well. 

Now I did run Merlin VSM speakers some years ago, somewhat similar specs to the AN's, used those with both push pull and 845 SET amp, always preferred them with 845, bass much better than any EL34 and mids better than any KT series. Just for kicks tried them with some 2a3 monoblocks I had, no way, sounded like one of those pocket transistor radios. Of course 300B somewhere in the middle. I just wouldn't be so quick to get rid of what you have, your Aric audio amp and pre are fine pieces, almost pulled the trigger myself on his two enclosure 300B amps.

What 300B's are you running? The 'premium' tubes make all the difference. I originally ran the Shuguang Black Treasures, generally considered one of the best or best of the 'affordable' 300B. Then moved to Psvane Acme, wow, that woke up my custom build 300B monoblocks, just far more insight, micro, macro dynamics, then I move to the Western Electric, notable increase in transparency. Power tubes make a big difference in SET, the same with my 845 SET's.

I should also note since REL's designed to connect to speaker binding post, they take on sound characteristics of amp to some extent, most seamless integration of subs I've tired, this vs. far more powerful subs using dsp. Some speakers just need a little bit more oomph, reach in bass, these not like bookshelf speakers that need crossover set at higher freq. don't need these massive subs  My listening room 13'W x well over 30' L, I sometimes listen to electronic dance music and hard rock, my 'little' T9x pair of REL's do just fine, don't shake the room like my larger Genesis clone subs (Wyred4Sound), but the integration on all genres of music better.

As I mentioned above, I have not heard your amps, but the description suggests that it is very well done--the construction is good, it uses an interstage transformer to help drive the 300B properly, etc.  Nonetheless, if you find the sound is not quite what you want, it is worth exploring alternatives.  I would not automatically assume it is the speaker that should be replaced, particularly since it is not that easy to find speakers that have all of the positive attributes of the AN-E.  I would at least try different speaker placement, room treatments, perhaps different tubes in the amp, even different amps if you can find loaners.  In looking at different amps, don't automatically assume that SET amps are "magical" and cannot be touched by other topologies.  I've heard great pushpull amps that also sound great with high efficiency speakers and OTL amps that also deliver killer sound.  

At Deja Vu, I've heard the AN-E's with Synthesis Audio amps (pushpull KT66) and prefer them over Audio Note amps because they have a punchier sound.  Perhaps you can find something like that to try.  

Sns, I use 4 Western Electric, Telefunken as my 6v6 and 2 6sn7 Raytheon’s as the I put tubes(supposed to be bass heavy). In the preamp I use 2 Raytheon and 2 RCA’s. I really love the sound of this particular set up. I’ve tube rolled a bit and found this arrangement quite nice. 

Larry. My first tube amp from Vu was a Synthesis push pull el84 amp. It had that punch for sure. I matched it with Zu Soul Supreme speakers and had extreme ear fatigue really quickly. Headache would last hours. I tried all sorts of treatments around the room. In my rush to find a fix, I sold the Zu’s and decided to sell the amp as well. The amp had to be biased by hand, by going in with a screw driver next to that power storing transformer! It also had a built in dac. At the time, I wanted to play around with various sounding dacs and find one that really was my sound. So off it went. That Synthesis a-40 gets great reviews but same situation. 
So, depending on trade in or personal sale, I may try the Soro se signature or scrap tubes and try a Pass Labs int-60. Both are 1 box solutions.