The challenge for a monitor/sub combo in a large room is for the monitors to be able to fill the room with realistic sound levels. I also agree with Beheme that monitor-sub integration is non-trivial. The advantage for the combo would be the opportunity to optimize soundstage imaging with proper monitor placement and to optimize room resonance control with proper sub placement.
Large speakers without subwoofer support often require large rooms. Listeners have to be able to get far enough away from the speakers that their drivers can integrate together to provide good imaging. Too close and the distances between drivers begin to impose their own dimensionality on the sound. Of course, the complementary benefit is that bigger speakers generally can go louder, so as to generate adequate volume in a big room.
Perhaps somewhere in between is the most flexible compromise. Maybe a monitor/sub combo with larger (the old "bookshelf" sized?) monitors -- loud enough for all but the largest rooms, but not too big and retaining placement flexibilty.
Large speakers without subwoofer support often require large rooms. Listeners have to be able to get far enough away from the speakers that their drivers can integrate together to provide good imaging. Too close and the distances between drivers begin to impose their own dimensionality on the sound. Of course, the complementary benefit is that bigger speakers generally can go louder, so as to generate adequate volume in a big room.
Perhaps somewhere in between is the most flexible compromise. Maybe a monitor/sub combo with larger (the old "bookshelf" sized?) monitors -- loud enough for all but the largest rooms, but not too big and retaining placement flexibilty.