Unfortunately my experience is that they are contextual: their specific resistance, impedance and capacitance characteristics work well in one setting and are negative in another, This applies equally to digital and analogue connections. And the permutations from shielding, gauges, metallurgy and connectors are mindboggling. The best solution therefore is no cable. Think Uptone USPCB…
That said they are a major component in system synergy and a bl**dy money pit.