I'm sure you can mix them, but won't you always be wondering if you are getting the best performance possible?
As with anything to do with this hobby, having at least matched pairs seems to be critical
When I had my tube amp I always purchased matched quads for the power side and matched pairs for the others.
I just reconciled myself to the matching aspect of tubes and bit the bullet - probably spent too much on tubes, but it sounded very nice
If you know the spec of the tubes you have you might find a vendor that will closely match a new tube for you.
As with anything to do with this hobby, having at least matched pairs seems to be critical
When I had my tube amp I always purchased matched quads for the power side and matched pairs for the others.
I just reconciled myself to the matching aspect of tubes and bit the bullet - probably spent too much on tubes, but it sounded very nice
If you know the spec of the tubes you have you might find a vendor that will closely match a new tube for you.