Great sized room and no spousal acceptance factor and you are good to go.
I would look at where you should be when done. You want equal quality from source to speakers and two channel only stuff is way better than home theater components. Especially the source. When putting together a whole system, lots of research and listening is required to make sure the equipment has the kind of sound you want... like highly detailed with slam, warm, or natural... etc. There are brands that specialize in each. But assuming you are choosing the brands that play to your tastes and are of the best value at the investment level, then I recommend the approximate investment of 35% speaker, 15% streamer, 15% DAC, 15% preamp and `15% amp. Surround processors are not good two channel sources. Then after a year and all is broken in and positioned, start upgrading interconnects and power cords... etc.
One other thought... is there any chance this is a revenge purchase? Big, loud and ugly (to females)? If there is any chance, I would slow down, and go auditioning systems to find the sound you are looking for. I would listen to B&W, Wilson, Sonus Faber and Focal speaker based systems. They are main stream and make some of the finest speakers on the planet.