If that were my room, I'd certainly go with a great pair of bookshelf speakers.....and if you find later you need more bass, then you can add a small sub. My first thought would be to find speakers that are comfortable being placed nearer the the wall behind them.....acoustic suspension, front ported, or passive radiators.
I have not done it, but Dirac Live might be of help as well.....I think Mini DSP has some add on devices?