Yes, it is possible that a preamp or source component could be having a problem with one channel. It is also possible that a cable (interconnect, speaker cable) could be having a problem. Swap one item at a time until you identify the culprit. Changing 3 sets of speakers I would assume that it is NOT the speakers, but best to switch them to different channels just to make sure.
Cheers,
John
Cheers,
John