What @soix said. It also depends on your cables. One advantage to AES/EBU is that quality cables are availble. Machine made cables like I2S and USB are less available in high quality.
There is no difference in sould based just on the connector. It is the implementation by the OEM and the cable.
My Grimm streamer has only AES/EBU output so I'm sure they focused on that.
My Innous has only USB so I'm sure they focused on that.
Both sound excellent.
Jerry